An aid in the assessment of the degree of in vivo expression of the dopamine transporter (DaT)
• DaTQUANT assists in the detection and quantification of the loss of functional striatal dopaminergic neuron terminals, a loss correlated with Parkinson's disease
• Quantitative analysis may help assess the extent and intensity of the striatal 123I-ioflupane signal
Quantification results are indicated for left and right striatal binding ratios, putamen/caudate ratios, and left/right asymmetry. Values are for illustrative purposes only.
Automated processing ensures objective, accurate, and reproducible results
• Uses a predefined 123I-ioflupane VOI template for automatic asymmetry measurements and putamen/caudate update ratios
-Offers the option for manual adjustment of VOI placement
-95% of more than 200 images tested required no user intervention for VOI placement adjustment1
• Reduces variation in comparison to normal database by reconstructing SPECT data with same parameters applied to normal database
• Orients the image automatically for optimal visual assessment and removal of head-tilt artifacts
A normal database developed from healthy volunteers who contributed to the Parkinson's Progression Markers Initiative, a comprehensive study of patients with Parkinson's disease2
• In less than one minute, generates quantification results including comparison to age-matched normal volunteers.
• Normal database has been validated for use with images acquired on a variety of multiheaded SPECT cameras
• Users have the ability to create a customized normal database that enables comparison to a site-specific normal population of images
DaT, dopamine transporter; SBR, striatal binding ratio; VOI, volume of interest; SPECT, single-photon emission computed tomography; PDF, portable document format; DICOM, Digital Imaging and Communications in Medicine; PACS, picture archiving and communication system
1. Internal verification testing data on file. GE Healthcare; 2015.
2. Parkinson's Progression Markers Initiative. PPMI-info.org. Accessed 2018.